Buffalo Bills at Jets, 1 p.m., CBS

Line: Bills -13 | Total: 47.5

The Bills (5-3) will be hungry and motivated after their embarrassing loss to the Jaguars, and their defense, which ranks first in fewest passing yards allowed (1,416), should be able to chomp on a Jets (2-6) team that will start an injured backup quarterback.

Jets Coach Robert Saleh said Wednesday that Mike White will again start in place of Zach Wilson (knee). White has thrown for five touchdowns in seven quarters, but got a nerve contusion in his right forearm against the Colts last week. Buffalo should put up most of the points expected in this one. Pick: Bills -13

Detroit Lions at Pittsburgh Steelers, 1 p.m., Fox

Line: Steelers -9.5 | Total: 43.5

Don’t bet on the Lions (0-8) to finally win their first game this week. The Steelers have allowed the second-fewest yards in the N.F.L. (2,420) and T.J. Watt, who has posted the second-most sacks this season (11.5) should be in contention for the Defensive Player of the Year Award. Detroit’s moral victories of playing competitively against good teams have not yet translated to actual wins, and until the Lions show they can both make good calls and execute them late in games, they will continue to justify the spread. Steelers quarterback Ben Roethlisberger is out, it was announced Saturday night, because he is on the Covid-19 protocol list. Pick: Steelers -9.5

Tampa Bay Buccaneers at Washington Footballers, 1 p.m., Fox

Line: Buccaneers -10 | Total: 51.5

A rematch of last season’s N.F.C. wild-card matchup that Tampa Bay won 31-23 shouldn’t be as close this time around. The defense that carried the Footballers (2-6) to the playoffs in the 2020 season has allowed the sixth-most passing yards in the league. That benefits the Buccaneers (6-2) as Tom Brady ranks second in passing yards (2,650) and first in touchdowns (25), even with the playing statuses of receiver Antonio Brown (ankle) and tight end Rob Gronkowski (back) still unclear. Pick: Buccaneers -10

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